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Hepatic biotransformation of MLN8054 was analyzed in vitro applying human liver S9 fractions (Info on file, Millennium). Glucuronidation with the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant system of biotransformation, Hydroxylation with the azepine moiety of MLN8054 was the major stage 1 biotransformation pathway. Gluc